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CGBVS Target Proteins

G-Protein Coupled Receptors (GPCR)

Classification based on number of interaction data
Very good: 500 or more, Good: 100-499, Fair: 1-99

5HT1A_HUMAN P08908 5-hydroxytryptamine receptor 1A Very good
5HT1B_HUMAN P28222 5-hydroxytryptamine receptor 1B Very good
5HT1D_HUMAN P28221 5-hydroxytryptamine receptor 1D Very good
5HT1E_HUMAN P28566 5-hydroxytryptamine receptor 1E Very good
5HT1F_HUMAN P30939 5-hydroxytryptamine receptor 1F Very good
5HT2A_HUMAN P28223 5-hydroxytryptamine receptor 2A Very good
5HT2B_HUMAN P41595 5-hydroxytryptamine receptor 2B Very good
5HT2C_HUMAN P28335 5-hydroxytryptamine receptor 2C Very good
5HT4R_HUMAN Q13639 5-hydroxytryptamine receptor 4 Very good
5HT5A_HUMAN P47898 5-hydroxytryptamine receptor 5A Very good
5HT6R_HUMAN P50406 5-hydroxytryptamine receptor 6 Very good
5HT7R_HUMAN P34969 5-hydroxytryptamine receptor 7 Very good
AA1R_HUMAN P30542 Adenosine receptor A1 Very good
AA2AR_HUMAN P29274 Adenosine receptor A2a Very good
AA2BR_HUMAN P29275 Adenosine receptor A2b Very good
AA3R_HUMAN P33765 Adenosine receptor A3 Very good
ACM1_HUMAN P11229 Muscarinic acetylcholine receptor M1 Very good
ACM2_HUMAN P08172 Muscarinic acetylcholine receptor M2 Very good
ACM3_HUMAN P20309 Muscarinic acetylcholine receptor M3 Very good
ACM4_HUMAN P08173 Muscarinic acetylcholine receptor M4 Very good
ACM5_HUMAN P08912 Muscarinic acetylcholine receptor M5 Very good
ACTHR_HUMAN Q01718 Adrenocorticotropic hormone receptor Very good
ADA1A_HUMAN P35348 Alpha-1A adrenergic receptor Very good
ADA1B_HUMAN P35368 Alpha-1B adrenergic receptor Very good
ADA1D_HUMAN P25100 Alpha-1D adrenergic receptor Very good
ADA2A_HUMAN P08913 Alpha-2A adrenergic receptor Very good
ADA2B_HUMAN P18089 Alpha-2B adrenergic receptor Very good
ADA2C_HUMAN P18825 Alpha-2C adrenergic receptor Very good
ADRB1_HUMAN P08588 Beta-1 adrenergic receptor Very good
ADRB2_HUMAN P07550 Beta-2 adrenergic receptor Very good
ADRB3_HUMAN P13945 Beta-3 adrenergic receptor Very good
AGTR1_HUMAN P30556 Type-1 angiotensin II receptor Very good
AGTR2_HUMAN P50052 Type-2 angiotensin II receptor Very good
APJ_HUMAN P35414 Apelin receptor Fair
BKRB1_HUMAN P46663 B1 bradykinin receptor Very good
BKRB2_HUMAN P30411 B2 bradykinin receptor Very good
BRS3_HUMAN P32247 Bombesin receptor subtype-3 Very good
C3AR_HUMAN Q16581 C3a anaphylatoxin chemotactic receptor Very good
C5AR_HUMAN P21730 C5a anaphylatoxin chemotactic receptor Very good
CALCR_HUMAN P30988 Calcitonin receptor Good
CALRL_HUMAN Q16602 Calcitonin gene-related peptide type 1 receptor Very good
CASR_HUMAN P41180 Extracellular calcium-sensing receptor Very good
CCKAR_HUMAN P32238 Cholecystokinin receptor type A Very good
CCR10_HUMAN P46092 C-C chemokine receptor type 10 Very good
CCR1_HUMAN P32246 C-C chemokine receptor type 1 Very good
CCR2_HUMAN P41597 C-C chemokine receptor type 2 Very good
CCR3_HUMAN P51677 C-C chemokine receptor type 3 Very good
CCR4_HUMAN P51679 C-C chemokine receptor type 4 Very good
CCR5_HUMAN P51681 C-C chemokine receptor type 5 Very good
CCR6_HUMAN P51684 C-C chemokine receptor type 6 Very good
CCR7_HUMAN P32248 C-C chemokine receptor type 7 Very good
CCR8_HUMAN P51685 C-C chemokine receptor type 8 Very good
CCR9_HUMAN P51686 C-C chemokine receptor type 9 Very good
CCRL1_HUMAN Q9NPB9 C-C chemokine receptor type 11 Very good
CLTR1_HUMAN Q9Y271 Cysteinyl leukotriene receptor 1 Very good
CLTR2_HUMAN Q9NS75 Cysteinyl leukotriene receptor 2 Very good
CML1_HUMAN Q99788 Chemokine-like receptor 1 Fair
CNR1_HUMAN P21554 Cannabinoid receptor 1 Very good
CNR2_HUMAN P34972 Cannabinoid receptor 2 Very good
CRFR1_HUMAN P34998 Corticotropin-releasing factor receptor 1 Very good
CRFR2_HUMAN Q13324 Corticotropin-releasing factor receptor 2 Very good
CX3C1_HUMAN P49238 CX3C chemokine receptor 1 Good
CXCR1_HUMAN P25024 C-X-C chemokine receptor type 1 Very good
CXCR2_HUMAN P25025 C-X-C chemokine receptor type 2 Very good
CXCR3_HUMAN P49682 C-X-C chemokine receptor type 3 Very good
CXCR4_HUMAN P61073 C-X-C chemokine receptor type 4 Very good
CXCR5_HUMAN P32302 C-X-C chemokine receptor type 5 Very good
CXCR7_HUMAN P25106 C-X-C chemokine receptor type 7 Good
DRD1_HUMAN P21728 D(1A) dopamine receptor Very good
DRD2_HUMAN P14416 D(2) dopamine receptor Very good
DRD3_HUMAN P35462 D(3) dopamine receptor Very good
DRD4_HUMAN P21917 D(4) dopamine receptor Very good
DRD5_HUMAN P21918 D(1B) dopamine receptor Very good
EDNRA_HUMAN P25101 Endothelin-1 receptor Very good
EDNRB_HUMAN P24530 Endothelin B receptor Very good
FFAR1_HUMAN O14842 Free fatty acid receptor 1 Very good
FFAR2_HUMAN O15552 Free fatty acid receptor 2 Fair
FFAR3_HUMAN O14843 Free fatty acid receptor 3 Fair
FPR1_HUMAN P21462 fMet-Leu-Phe receptor Fair
FPR2_HUMAN P25090 N-formyl peptide receptor 2 Good
FPR3_HUMAN P25089 N-formyl peptide receptor 3 Fair
FSHR_HUMAN P23945 Follicle-stimulating hormone receptor Very good
GABR1_HUMAN Q9UBS5 Gamma-aminobutyric acid type B receptor subunit 1 Very good
GABR2_HUMAN O75899 Gamma-aminobutyric acid type B receptor subunit 2 Very good
GALR1_HUMAN P47211 Galanin receptor type 1 Very good
GALR2_HUMAN O43603 Galanin receptor type 2 Good
GALR3_HUMAN O60755 Galanin receptor type 3 Very good
GASR_HUMAN P32239 Gastrin/cholecystokinin type B receptor Very good
GHRHR_HUMAN Q02643 Growth hormone-releasing hormone receptor Good
GHSR_HUMAN Q92847 Growth hormone secretagogue receptor type 1 Very good
GIPR_HUMAN P48546 Gastric inhibitory polypeptide receptor Good
GLP1R_HUMAN P43220 Glucagon-like peptide 1 receptor Very good
GLP2R_HUMAN O95838 Glucagon-like peptide 2 receptor Fair
GLR_HUMAN P47871 Glucagon receptor Very good
GNRHR_HUMAN P30968 Gonadotropin-releasing hormone receptor Very good
GP116_HUMAN Q8IZF2 Probable G-protein coupled receptor 116 Very good
GP119_HUMAN Q8TDV5 Glucose-dependent insulinotropic receptor Very good
GP142_HUMAN New Q7Z601 Probable G-protein coupled receptor 142 Fair
GP182_HUMAN O15218 G-protein coupled receptor 182 Fair
GPBAR_HUMAN Q8TDU6 G-protein coupled bile acid receptor 1 Very good
GPC6A_HUMAN Q5T6X5 G-protein coupled receptor family C group 6 member A Fair
GPER_HUMAN Q99527 G-protein coupled estrogen receptor 1 Fair
GPR17_HUMAN Q13304 Uracil nucleotide/cysteinyl leukotriene receptor Fair
GPR18_HUMAN Q14330 N-arachidonyl glycine receptor Fair
GPR1_HUMAN P46091 G-protein coupled receptor 1 Fair
GPR34_HUMAN Q9UPC5 Probable G-protein coupled receptor 34 Good
GPR35_HUMAN Q9HC97 G-protein coupled receptor 35 Good
GPR39_HUMAN New O43194 G-protein coupled receptor 39 Fair
GPR4_HUMAN P46093 G-protein coupled receptor 4 Good
GPR55_HUMAN Q9Y2T6 G-protein coupled receptor 55 Very good
GPR83_HUMAN Q9NYM4 Probable G-protein coupled receptor 83 Fair
GPR84_HUMAN Q9NQS5 G-protein coupled receptor 84 Fair
GRM1_HUMAN Q13255 Metabotropic glutamate receptor 1 Very good
GRM2_HUMAN Q14416 Metabotropic glutamate receptor 2 Very good
GRM3_HUMAN Q14832 Metabotropic glutamate receptor 3 Very good
GRM4_HUMAN Q14833 Metabotropic glutamate receptor 4 Very good
GRM5_HUMAN P41594 Metabotropic glutamate receptor 5 Very good
GRM6_HUMAN O15303 Metabotropic glutamate receptor 6 Very good
GRM7_HUMAN Q14831 Metabotropic glutamate receptor 7 Very good
GRM8_HUMAN O00222 Metabotropic glutamate receptor 8 Very good
GRPR_HUMAN P30550 Gastrin-releasing peptide receptor Good
HCAR1_HUMAN New Q9BXC0 Hydroxycarboxylic acid receptor 1 Fair
HCAR2_HUMAN Q8TDS4 Hydroxycarboxylic acid receptor 2 Very good
HCAR3_HUMAN P49019 Hydroxycarboxylic acid receptor 3 Very good
HRH1_HUMAN P35367 Histamine H1 receptor Very good
HRH2_HUMAN P25021 Histamine H2 receptor Very good
HRH3_HUMAN Q9Y5N1 Histamine H3 receptor Very good
HRH4_HUMAN Q9H3N8 Histamine H4 receptor Very good
KISSR_HUMAN Q969F8 KiSS-1 receptor Fair
LPAR1_HUMAN Q92633 Lysophosphatidic acid receptor 1 Very good
LPAR2_HUMAN Q9HBW0 Lysophosphatidic acid receptor 2 Very good
LPAR3_HUMAN Q9UBY5 Lysophosphatidic acid receptor 3 Very good
LPAR4_HUMAN Q99677 Lysophosphatidic acid receptor 4 Fair
LPAR5_HUMAN Q9H1C0 Lysophosphatidic acid receptor 5 Fair
LPAR6_HUMAN P43657 Lysophosphatidic acid receptor 6 Fair
LSHR_HUMAN P22888 Lutropin-choriogonadotropic hormone receptor Very good
LT4R1_HUMAN Q15722 Leukotriene B4 receptor 1 Very good
LT4R2_HUMAN Q9NPC1 Leukotriene B4 receptor 2 Very good
MC3R_HUMAN P41968 Melanocortin receptor 3 Very good
MC4R_HUMAN P32245 Melanocortin receptor 4 Very good
MC5R_HUMAN P33032 Melanocortin receptor 5 Very good
MCHR1_HUMAN Q99705 Melanin-concentrating hormone receptor 1 Very good
MCHR2_HUMAN Q969V1 Melanin-concentrating hormone receptor 2 Very good
MRGX1_HUMAN Q96LB2 Mas-related G-protein coupled receptor member X1 Fair
MRGX2_HUMAN Q96LB1 Mas-related G-protein coupled receptor member X2 Fair
MSHR_HUMAN Q01726 Melanocyte-stimulating hormone receptor Very good
MTLR_HUMAN O43193 Motilin receptor Very good
MTR1A_HUMAN P48039 Melatonin receptor type 1A Very good
MTR1B_HUMAN P49286 Melatonin receptor type 1B Very good
MTR1L_HUMAN Q13585 Melatonin-related receptor Good
NK1R_HUMAN P25103 Substance-P receptor Very good
NK2R_HUMAN P21452 Substance-K receptor Very good
NK3R_HUMAN P29371 Neuromedin-K receptor Very good
NMBR_HUMAN P28336 Neuromedin-B receptor Very good
NMUR1_HUMAN Q9HB89 Neuromedin-U receptor 1 Fair
NMUR2_HUMAN Q9GZQ4 Neuromedin-U receptor 2 Fair
NPBW1_HUMAN P48145 Neuropeptides B/W receptor type 1 Good
NPBW2_HUMAN New P48146 Neuropeptides B/W receptor type 2 Fair
NPFF1_HUMAN Q9GZQ6 Neuropeptide FF receptor 1 Good
NPFF2_HUMAN Q9Y5X5 Neuropeptide FF receptor 2 Good
NPSR1_HUMAN Q6W5P4 Neuropeptide S receptor Very good
NPY1R_HUMAN P25929 Neuropeptide Y receptor type 1 Very good
NPY2R_HUMAN P49146 Neuropeptide Y receptor type 2 Very good
NPY4R_HUMAN P50391 Neuropeptide Y receptor type 4 Very good
NPY5R_HUMAN Q15761 Neuropeptide Y receptor type 5 Very good
NPY6R_HUMAN Q99463 Putative neuropeptide Y receptor type 6 Very good
NTR1_HUMAN P30989 Neurotensin receptor type 1 Very good
NTR2_HUMAN O95665 Neurotensin receptor type 2 Very good
O3FA1_HUMAN Q5NUL3 Omega-3 fatty acid receptor 1 Good
OPN4_HUMAN Q9UHM6 Melanopsin Fair
OPRD_HUMAN P41143 Delta-type opioid receptor Very good
OPRK_HUMAN P41145 Kappa-type opioid receptor Very good
OPRM_HUMAN P35372 Mu-type opioid receptor Very good
OPRX_HUMAN P41146 Nociceptin receptor Very good
OPSD_HUMAN P08100 Rhodopsin Fair
OR1D2_HUMAN P34982 Olfactory receptor 1D2 Fair
OX1R_HUMAN O43613 Orexin receptor type 1 Very good
OX2R_HUMAN O43614 Orexin receptor type 2 Very good
OXER1_HUMAN Q8TDS5 Oxoeicosanoid receptor 1 Fair
OXGR1_HUMAN New Q96P68 2-oxoglutarate receptor 1 Fair
OXYR_HUMAN P30559 Oxytocin receptor Very good
P2RY1_HUMAN P47900 P2Y purinoceptor 1 Very good
P2RY2_HUMAN P41231 P2Y purinoceptor 2 Very good
P2RY4_HUMAN P51582 P2Y purinoceptor 4 Good
P2RY6_HUMAN Q15077 P2Y purinoceptor 6 Good
P2RY8_HUMAN Q86VZ1 P2Y purinoceptor 8 Good
P2Y10_HUMAN O00398 Putative P2Y purinoceptor 10 Good
P2Y11_HUMAN Q96G91 P2Y purinoceptor 11 Good
P2Y12_HUMAN Q9H244 P2Y purinoceptor 12 Very good
P2Y13_HUMAN Q9BPV8 P2Y purinoceptor 13 Good
P2Y14_HUMAN Q15391 P2Y purinoceptor 14 Good
PACR_HUMAN P41586 Pituitary adenylate cyclase-activating polypeptide type I receptor Fair
PAR1_HUMAN P25116 Proteinase-activated receptor 1 Very good
PAR2_HUMAN P55085 Proteinase-activated receptor 2 Very good
PAR3_HUMAN O00254 Proteinase-activated receptor 3 Fair
PAR4_HUMAN Q96RI0 Proteinase-activated receptor 4 Good
PD2R2_HUMAN Q9Y5Y4 Prostaglandin D2 receptor 2 Very good
PD2R_HUMAN Q13258 Prostaglandin D2 receptor Very good
PE2R1_HUMAN P34995 Prostaglandin E2 receptor EP1 subtype Very good
PE2R2_HUMAN P43116 Prostaglandin E2 receptor EP2 subtype Very good
PE2R3_HUMAN P43115 Prostaglandin E2 receptor EP3 subtype Very good
PE2R4_HUMAN P35408 Prostaglandin E2 receptor EP4 subtype Very good
PF2R_HUMAN P43088 Prostaglandin F2-alpha receptor Very good
PI2R_HUMAN P43119 Prostacyclin receptor Very good
PKR1_HUMAN Q8TCW9 Prokineticin receptor 1 Good
PKR2_HUMAN Q8NFJ6 Prokineticin receptor 2 Very good
PSYR_HUMAN Q8IYL9 Psychosine receptor Fair
PTAFR_HUMAN P25105 Platelet-activating factor receptor Very good
PTH1R_HUMAN Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor Very good
PTH2R_HUMAN P49190 Parathyroid hormone 2 receptor Good
QRFPR_HUMAN New Q96P65 Pyroglutamylated RFamide peptide receptor Fair
RL3R1_HUMAN New Q9NSD7 Relaxin-3 receptor 1 Fair
RL3R2_HUMAN Q8TDU9 Relaxin-3 receptor 2 Fair
RXFP1_HUMAN Q9HBX9 Relaxin receptor 1 Very good
S1PR1_HUMAN P21453 Sphingosine 1-phosphate receptor 1 Very good
S1PR2_HUMAN O95136 Sphingosine 1-phosphate receptor 2 Very good
S1PR3_HUMAN Q99500 Sphingosine 1-phosphate receptor 3 Very good
S1PR4_HUMAN O95977 Sphingosine 1-phosphate receptor 4 Very good
S1PR5_HUMAN Q9H228 Sphingosine 1-phosphate receptor 5 Very good
SCTR_HUMAN New P47872 Secretin receptor Fair
SSR1_HUMAN P30872 Somatostatin receptor type 1 Very good
SSR2_HUMAN P30874 Somatostatin receptor type 2 Very good
SSR3_HUMAN P32745 Somatostatin receptor type 3 Very good
SSR4_HUMAN P31391 Somatostatin receptor type 4 Very good
SSR5_HUMAN P35346 Somatostatin receptor type 5 Very good
SUCR1_HUMAN Q9BXA5 Succinate receptor 1 Fair
T2R31_HUMAN New P59538 Taste receptor type 2 member 31 Fair
TA2R1_HUMAN Q9NYW7 Taste receptor type 2 member 1 Fair
TA2R_HUMAN P21731 Thromboxane A2 receptor Very good
TAAR1_HUMAN Q96RJ0 Trace amine-associated receptor 1 Very good
TBB3_HUMAN Q13509 Tubulin beta-3 chain Good
TRFR_HUMAN P34981 Thyrotropin-releasing hormone receptor Good
TS1R1_HUMAN Q7RTX1 Taste receptor type 1 member 1 Good
TS1R2_HUMAN Q8TE23 Taste receptor type 1 member 2 Good
TS1R3_HUMAN Q7RTX0 Taste receptor type 1 member 3 Good
TSHR_HUMAN P16473 Thyrotropin receptor Very good
UR2R_HUMAN Q9UKP6 Urotensin-2 receptor Very good
V1AR_HUMAN P37288 Vasopressin V1a receptor Very good
V1BR_HUMAN P47901 Vasopressin V1b receptor Very good
V2R_HUMAN P30518 Vasopressin V2 receptor Very good
VIPR1_HUMAN P32241 Vasoactive intestinal polypeptide receptor 1 Fair
VIPR2_HUMAN P41587 Vasoactive intestinal polypeptide receptor 2 Fair

Prediction model updated on March 3, 2015